Can spraying Round up on a sugar maple kill it? I have a poison ivy vine climbing one of my sugar maples. I'd like to get rid of it (the PI) but am afraid to spray because I don't want to hurt the tree. Would I be better off just cutting the vine. One of my neighbors cleared some of the barrier between our properties and took the liberty of spraying all the poison ivy that was growing there. About a month later a large sugar maple that was growing there lost all of it's leaves and died. At the time we were just mystified by this, but now I'm wondering if she accidentally sprayed the tree as well.